L-Ascorbic acid | L-抗坏血酸 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 500 |
性能特点
L-Ascorbic acid (L-Ascorbate),一种电子供体,是一种内源性抗氧化剂。L-Ascorbic acid 选择性抑制 Cav3.2 通道 (Cav3.2 channels
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 50-81-7 | ¥500.00 | 询底价 |
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L-Ascorbic acid
CAS No. : 50-81-7
MCE 国际站:L-Ascorbic acid
产品活性:L-Ascorbic acid (L-Ascorbate),一种电子供体,是一种内源性抗氧化剂。L-Ascorbic acid 选择性抑制 Cav3.2 通道 (Cav3.2 channels),IC50 为 6.5 μM。L-Ascorbic acid 还是一种胶原沉积促进剂和弹性生成抑制剂。L-Ascorbic acid通过产生活性氧 (ROS) 和选择性损伤癌细胞表现出抗癌作用。
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Neuronal Signaling | Membrane Transporter/Ion Channel | Apoptosis
作用靶点:Reactive Oxygen Species | Calcium Channel | Apoptosis | Endogenous Metabolite
In Vitro: The anti-cancer effects of L-Ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of L-ascorbic acid. L-Ascorbic acid (0.1 μM-2 mM) exhibits anti-cancer effects according to SVCT-2 expression and L-ascorbic acid uptake. Human colorectal cancer cell lines displays differential responses to L-ascorbic acid, primarily depending on the expression level of SVCT-2.
In Vivo: L-Ascorbic acid/Tolbutamide produces hypoglycaemic activity in a dose dependant manner in normal (60 mg/kg) and diabetic (40 mg/kg) condition. In the presence of L-ascorbic acid, Tolbuatmide (20 mg/kg) produces early onset of action and maintained for longer period compared to Tolbutamide matching control.
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