Fc gamma RIIIA/CD16a 蛋白, Cynomolgus (HEK293, His) | MedChemExpress (MCE)

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His)

MCE 国际站：Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His)

FCGR3A 是一种免疫球蛋白 G Fc 部分的受体，可增强抗体依赖性细胞介导的细胞毒性和抗体依赖性病毒感染。FCGR3A 还是潜在的免疫致癌分子，与肿瘤免疫浸润水平有关。FCGR3A 常常用作前列腺癌 (PCa) 预后价值的生物标志物。Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) 是重组的 Fc gamma RIIIA/CD16a 蛋白，由 HEK293 表达，带有 C-6*His 标签。Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) 全长 186 个氨基酸，分子量为 30-40 kDa。

Synonyms: rCynFc-gamma receptor 3A/CD16a, His; Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3

Species: Cynomolgus

Source: HEK293

研究背景：FCGR3A is a receptor for the Fc portion of immunoglobulin G, an integral membrane glycoprotein expressed on natural killer (NK) cells anchored by a transmembrane peptide. Whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMNs), where the receptor is anchored via a phosphatidylinositol (PI) linkage. FCGR3A enhances antibody-dependent cell-mediated cytotoxicity and antibody-dependent viral infection. Differential analysis results of public databases show that FCGR3A is generally highly expressed in pan-cancers, and its expression has been confirmed to be related to the infiltration of multiple immune cells, the expression of multiple immune checkpoint genes and DNA mismatch repair genes in systemic cancers. There is a negative correlation between FCGR3A and DNA methylation levels. FCGR3A and HAVCR2 are highly expressed in PCa and are associated with BCR-free survival in PCa patients. Therefore, FCGR3A is a biomarker with potential prognostic value in prostate cancer (PCa). FCGR3A may also be an immuno-oncogenic molecule that correlates with the level of tumor immune infiltration and affects drug sensitivity. In addition, studies have found that FCGR3A gene duplications are associated with HIV-1 acquisition and that allelic variants in FCGR3A play a role in HIV-1 infection in infants and control susceptibility to HIV-1 infection.

蛋白编号：A0A140HDP8 (E21-G206)

基因 ID：102140945

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。