Sinapine | MedChemExpress (MCE)

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Sinapine

CAS No. : 18696-26-9

MCE 国际站：Sinapine

产品活性：Sinapine 是一种从十字花科物种的种子中分离出来的生物碱。Sinapine 具有抗炎，抗氧化，抗肿瘤，抗血管生成和放射防护作用。Sinapine 还是一种乙酰胆碱酯酶 (AChE) 抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。

研究领域：Neuronal Signaling  |  Membrane Transporter/Ion Channel

作用靶点：Cholinesterase (ChE)  |  P-glycoprotein

In Vitro: Sinapine (6 or 60 μM; 1 h) counteracts H₂O₂ and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes.
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity.
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease.
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.

In Vivo: Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.

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