Asiatic acid | 积雪草酸 | MedChemExpress (MCE)

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Asiatic acid

CAS No. : 464-92-6

MCE 国际站：Asiatic acid

产品活性：Asiatic acid，是在积雪草 (Centella asiatica) 中发现的一种五环三萜，具有抗癌活性。Asiatic acid 可诱导黑色素瘤细胞凋亡 (apoptosis)，并对人主动脉内皮细胞（HAEC）具有屏障保护作用。Asiatic acid 还具有抗炎活性，可抑制肿瘤坏死因子 (TNF)-α 诱导的内皮屏障功能障碍。Asiatic acid 还抑制 NLRP3 炎症小体激活和 NF-κB 通路，有效抑制大鼠炎症，并在大鼠脊髓损伤 (SCI) 模型中具有神经保护作用。

研究领域：Apoptosis  |  Anti-infection

作用靶点：Apoptosis  |  Parasite

In Vitro: Asiatic acid exerts barrier stabilizing effects against TNF-α by maintaining adherens junctions (AJs) and inhibiting tight junction (TJ) redistribution.
Asiatic acid (40 μM) stabilizes F-actin and diphosphate-MLC at the cell periphery and prevents their rearrangement stimulated by TNF-α (10 ng/mL; 1 h). However, Asiatic acid (10-30 μM; 6 h) cannot reduce F-actin aggregation.
Asiatic acid (40 μM; 6 h) preserves the network structure of cell-cell contact areas and abolishes TNF-α-induced structural reorganization of vascular endothelial (VE)-cadherin and β-catenin.
However, Asiatic acid (10-40 μM; 6 h) had no inhibitory effect on endothelial cell permeability increased by cytochalasin D (5 μM; 15 min). Asiatic acid increases the diphosphorylation of myosin light chain (MLC).

In Vivo: Asiatic acid (5-75 mg/kg; intragastric gavage once daily) effectively inhibited pelvic inflammatory disease (PID) in rats in a pathogen-induced disease model and exerted antioxidant and anti-inflammatory effect.
Asiatic acid (30 mg/kg, 75 mg/kg; intragastric injection, once daily) has neuroprotective effects on spinal cord injury (SCI) in rats by inhibiting inflammation and oxidative stres.

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