Endoplasmic Reticulum Stress Compound Library | 内质网应激化合物库 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 |
性能特点
Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third
Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of Endoplasmic reticulum stress (ER stress, ERS) and unfolded protein response (UPR) signaling pathways. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration and cancer. MCE Endoplasmic Reticulum Stress Compound Library contains 221 ER stress-related compounds that mainly target PERK, IRE1, ATF6, etc. MCE ER stress library is a useful tool for researching ER stress and related diseases.更多产品详情查看:www.medchemexpress.cn/screening/endoplasmic-reticulum-stress-compound-library.html
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