DMP 777 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 1863 |
性能特点
DMP 777 是一种有效的,选择性的,可口服的 human leukocyte elastase (HLE) 抑制剂。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 157341-41-8 | ¥1,863.00 | 询底价 |
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DMP 777
CAS No. : 157341-41-8
MCE 国际站:DMP 777
产品活性:DMP 777 是一种有效的,选择性的,可口服的 human leukocyte elastase (HLE) 抑制剂。
研究领域:Metabolic Enzyme/Protease
作用靶点:Elastase
In Vivo: DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered with omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats thatreceive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途