Perhexiline maleate | 马来酸哌克昔林 | MedChemExpress (MCE)

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Perhexiline maleate

CAS No. : 6724-53-4

MCE 国际站：Perhexiline maleate

产品活性：Perhexiline maleate 是一种具有口服活性的 CPT1 和 CPT2 抑制剂，可减少脂肪酸代谢。Perhexiline maleate 在肝细胞中诱导线粒体功能障碍和细胞凋亡 (apoptosis)。Perhexiline maleate 可穿过血脑屏障 (BBB)，并显示出抗肿瘤活性。Perhexiline maleate 可用于癌症和心绞痛等心血管疾病的研究。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Mitochondrial Metabolism  |  Apoptosis

In Vitro: Perhexiline (5-25 μM, 2-6 h) maleate reduces cell viability in HepG2 cells.
Perhexiline (5-25 μM, 2-6 h) maleate reduces cellular ATP content and Lactate dehydrogenase (LDH) release in HepG2 cells.
Perhexiline (20 μM, 2 h) maleate activates caspase 3/7 in HepG2 cells.
Perhexiline (5-25 μM, 4 h) maleate causes mitochondrial dysfunction in HepG2 cells.
Perhexiline (5 μM, 48 h) maleate selectively induces massive apoptosis in CLL cells (high expression of CPT).

In Vivo: Perhexiline (200 mg/kg, p.o., daily for 8 weeks) maleate reduces peripheral neural function in female DA rats.
Perhexiline (80 mg/kg, oral gavage, for 3 days) maleate demonstrates anti-tumor activity in glioblastoma mouse model.

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