Rheb inhibitor NR1 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 2750 |
性能特点
Rheb inhibitor NR1 是一种 Rheb 抑制剂,IC50 为 2.1 μM。Rheb inhibitor NR1 可直接结合 Rheb switch II 结构域,选择性抑制
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 2216763-38-9 | ¥2,750.00 | 询底价 |
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
Rheb inhibitor NR1
CAS No. : 2216763-38-9
MCE 国际站:Rheb inhibitor NR1
产品活性:Rheb inhibitor NR1 是一种 Rheb 抑制剂,IC50 为 2.1 μM。Rheb inhibitor NR1 可直接结合 Rheb switch II 结构域,选择性抑制 mTORC1 的激活。Rheb inhibitor NR1 抑制 mTORC1 驱动的 T389pS6K1 的磷酸化,并以剂量依赖的方式增加 S473pAKT 的磷酸化。Rheb inhibitor NR1 不影响 mTORC2 的活性。
研究领域:PI3K/Akt/mTOR
作用靶点:mTOR
In Vitro: NR1 (1-10 μM; 48 h) reduces the size of Jurkat cells.
?
NR1 (0.37-30 μM; 90 min for MCF-7 and TRI102; 24 h for PC3) inhibits the phosphorylation of T389pS6K1 and increases the phosphorylation of S473pAKT in MCF-7, TRI102 and PC3 cells.
?
NR1 (1-30 μM; 2.5 h) reduced protein synthesis in MCF-7.
In Vivo: NR1 (30 mg/kg; IP; single dosage) significantly reduces mTORC1 activity in both kidney and skeletal muscle, and exhibited a clear band shift for T37/464E-BP1 in skeletal muscle.
相关产品:Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Glucose Metabolism Compound Library | Targeted Diversity Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Mitochondrial Protection Compound Library | Highly Selective Inhibitors Library | Serine/Threonine Kinase Inhibitor Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Radioprotector Library | Rapamycin | Everolimus | MHY1485 | Torin 1 | AZD-8055 | Sapanisertib | Dactolisib | Salidroside | Temsirolimus | Torin 2 | L-Leucine | Omipalisib | JR-AB2-011 | 3BDO | Camonsertib | RMC-5552 | Torkinib | PI-103 | Dihydromyricetin | NV-5138 | D-α-Hydroxyglutaric acid disodium | Vistusertib | hSMG-1 inhibitor 11j | Polyphyllin I | Aloe emodin | PF-04691502 | Daphnetin | KU-0063794 | Cryptochlorogenic acid
热门产品线:重组蛋白 | 药物筛选 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
![MCE Hotline: 4008203792 | 中国现货 - 全球文献引用 - 高纯度高品质 - 全方位技术支持](https://file.medchemexpress.cn/web-groups/product-type/7.jpg)
Rheb inhibitor NR1 | MedChemExpress (MCE)信息由MedChemExpress (MCE)为您提供,如您想了解更多关于Rheb inhibitor NR1 | MedChemExpress (MCE)报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途