Tat-NR2Baa | MedChemExpress (MCE)

Tat-NR2Baa 产品活性：Tat-NR2BAA 是 Tat-NR2B9c (HY-P0117) 的对照肽 (control peptide)，没有活性。Tat-NR2BAA 的序列与 Tat-NR2B9c 相似，但在 COOH 末端 tSXV 基序中有一个双点突变，这使得它无法结合 PSD-95。Tat-NR2B9c 是一种可通透细胞膜的多肽，破坏 PSD-95/NMDAR 的结合。 产品来源： https://www.medchemexpress.cn/tat-nr2baa.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Immunology/Inflammation 作用靶点：iGluR | NO Synthase In Vitro: Tat-NR2BAA (125 ng; 20 mins) does not effects interactions between PSD-95 and NR2B subunits. In contrast, coimmunoprecipitation of PSD-95 with NR2B subunits is markedly decreased in rats pretreated with the disrupting peptide Tat-NR2B9c in lumbar dorsal horn tissue. Tat-NR2Baa (125 ng or 1.25 μg; 20 minutes before collection of lumbar dorsal horn tissue) is the control group of Tat-NR2B9c. Tat-NR2B9c produces a significant and robust reduction of postdischarge, indicating the hyperexcitability of the cell. But Tat-NR2Baa has no effects, even at a dose 100× greater than the active peptide Tat-NR2B9c (HY-P0117).Tat-NR2Baa (1 μM; pre-treatment 1 hour) is the control group in the Co-IP assay. Tat-NR2B9c (1 μM) disrupts NR2B/PSD95 interaction, and the coupling of NR2B to PSD-95 is more sensitive than NR2A/PSD95 to disruption in hippocampal neurons. 相关产品：Bioactive Compound Library Plus | Peptide Library | Corticosterone | L-NAME hydrochloride | Mifepristone | Dizocilpine maleate | D-AP5 | NMDA | Midostaurin | L-Glutamic acid | L-Arginine | Evans Blue | CNQX | Kynurenic acid | Glycine | DMPO | L-Phenylalanine | NBQX | S-Nitroso-N-acetyl-DL-penicillamine | 1400W Dihydrochloride | Quinolinic acid | DETA NONOate | Cycloleucine | Human serum albumin | Isoquercetin | Ethacrynic acid | Methylene Blue | Fucoxanthin | L-NMMA acetate | Chondroitin sulfate | Tetrahydrobiopterin | Ifenprodil tartrate 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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