PrP (106-126) | MedChemExpress (MCE)

PrP (106-126) 产品活性：PrP (106-126) 是与朊病毒蛋白的淀粉样区域相对应的多肽段，它的生化特性类似于朊病毒蛋白的感染区域。 产品来源： https://www.medchemexpress.cn/PrP_106-126.html 研究领域：Others 作用靶点：Others In Vitro: PrP (106-126) (100 μM) induces mTOR phosphorylation over time in N2a cells. PrP (106-126)-treated cells show significantly increased ROS production in comparison with that of PBS-treated control cells. Knockdown of PRAS40 enhances PrP (106-126)-induced apoptosis. PRAS40 alleviates PrP (106-126)-induced neuronal apoptosis via mTOR-AKT activation. PrP (106-126) interacts selectively with porcine brain endothelial cells (PBEC) via their luminal side, and causes cumulative cell death, as shown by lactate dehydrogenase release, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction, Caspase 3 induction and direct cell counting. In addition, PrP (106-126), but not its corresponding scrambled peptide, produces a 50% reduction of the trans-endothelial electrical resistance, while the PBEC maintained confluency. 相关产品：Bioactive Compound Library Plus | Peptide Library | Digitonin | 5-Ph-IAA | FLAG peptide | 3X FLAG peptide | TCEP hydrochloride | Monocrotaline | Tocofersolan | Pronase E (Activity ≥ 7000 U/g) | DPPH | DNase I, Bovine pancreas | NMDI14 | O-Propargyl-Puromycin | Human IgG1 kappa, Isotype Control | Phytohemagglutinin | Hyaluronidase | Biotinyl tyramide | MYLS22 | Pertussis Toxin | N,N-Dimethylformamide | Kifunensine | OVA Peptide (323-339) | L-Tryptophan | 6-Aminonicotinamide | Lauryl maltose neopentyl glycol | Alkyne-phenol | Potassium oxonate | OVA Peptide(257-264) TFA | CHAPS | Teriparatide 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途