Cytosporone B | MedChemExpress (MCE)

Cytosporone B 产品活性：Cytosporone B (Csn-B; Dothiorelone G) 是天然存在的核孤儿受体Nur77/NR4A1激动剂，EC50值为0.278 nM。 产品来源： https://www.medchemexpress.cn/Cytosporone_B.html 研究领域：Vitamin D Related/Nuclear Receptor 作用靶点：Nuclear Hormone Receptor 4A/NR4A 结构分类：酚类 | 多酚类 | 其他类 | 结构分类 In Vitro: Cytosporone B targets the ligand binding domain of Nur77, which selectively stimulates the transactivational activity of Nur77. Cytosporone B induces luciferase activity in cells that are cotransfected with GAL4- Nur77 or GAL4-LBD. The EC50 of cytosporone B for Nur77 is 0.278 nM. Cytosporone B displays robust pro-apoptotic activity in gastric cancer cells BGC-823. 63.5% of the cells are apoptotic when treated with cytosporone B for 48 h. Cytosporone B shows selective effect on cancerous cells. Cytosporone B inhibits proliferation of human gastric cancer BGC-823 cells and human colon cancer SW620 cells by 470%, but it has a modest effect on human lung cancer H1299 cells and human hepatoma HepG2 cells. In Vivo: In the hepatocytes of wild-type mice, the transcriptional activity of the reporter is induced five-fold with cytosporone B treatment. In wild-type mice, cytosporone B treatment significantly increases glucose levels from 3.2 to 11.4 mM within the first 30 min, and thereafter blood glucose gradually decreased before reaching the initial level after 300 min. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Natural Product Library | Anti-Cancer Compound Library | CNS-Penetrant Compound Library | Anti-diabetic Compound Library | Phenols Library | Anti-Lung Cancer Compound Library | Microbial Metabolite Library | Transcription Factor-Targeted Library | Anti-Cancer Natural Product Library | Human Metabolite Library | Nuclear Receptor Compound Library | Bioactive Compound Library Max | DIM-C-pPhOH | DIM-C-pPhCO2Me | Amodiaquine dihydrochloride | TMPA | C-DIM12 | DIM-C-pPhOCH3 | IP7e | Triptohypol C | 4-PQBH | Nurr1 inverse agonist-1 | Nur77 modulator 1 | Nurr1 agonist 2 | 4A7C-301 | Amodiaquine-d10 hydrochloride | Amoitone B | Nur77 antagonist 1 | Nur77 modulator 2 | Nurr1 agonist 5 | Prostaglandin E2-biotin | THPN 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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