Gamabufotalin | 日蟾蜍他灵 | MedChemExpress (MCE)

Gamabufotalin 产品活性：Gamabufotalin (Gamabufagin)，蟾酥中主要的蟾蜍甾烯，由于其稳定性和低毒性被广泛用于癌症的研究。Gamabufotalin通过抑制VEGFR-2信号通路的激活来抑制血管生成。 产品来源： https://www.medchemexpress.cn/Gamabufotalin.html 研究领域：Protein Tyrosine Kinase/RTK 作用靶点：VEGFR 结构分类：甾体类 | 结构分类 In Vitro: Gamabufotalin (0-500 nM, 48 h) inhibits cell viability of human lung cancer A549, H1299, H322 cells, and inhibits colony formation and migration (0-100 nM, 48 h), with no cytotoxicity in human normal lung cell line (HLF cells). Gamabufotalin (0-100 nM, 12-48 h) inhibits COX-2 expression and inhibits NF-κB and p300 translocation in A549 cells. Gamabufotalin (0-100 nM, 12-48 h) induces apoptosis by activating the cytochrome c release and caspase-dependent apoptotic pathway in A549 cells. Gamabufotalin (0-100 nM, 48 h) induces hyperphosphorylation of p38, increases the expression of ATP1A3 and decreases AQP4 expression in U87 cells. Gamabufotalin (0-50 nM, 24 h) inhibits VEGF (50 ng/mL)-induced angiogenesis in an HUVECs in vitro angiogenesis tube formation assay. In Vivo: Gamabufotalin (5 and 20 mg/kg/day, i.p., for 17 days) inhibits tumor growth in the A549-xenografts mice. Gamabufotalin (1 mg/kg, i.p., three times per week) together with Temozolomide (HY-17364) (20 mg/kg. i.p., three times per week) shows a synergistic antitumor effect, and inhibits tumor growth and prolongs mice survival in mice U87 xenografts. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Kinase Inhibitor Library | Protein Tyrosine Kinase Compound Library | Natural Product Library | Anti-Cancer Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Lipid Compound Library | Medicine Food Homology Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Human Metabolite Library | Anti-Pulmonary Fibrosis Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Animal-Sourced Natural Product Library | Cytokine Inhibitors Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Bioactive Compound Library Max | Sorafenib | Lenvatinib | Bevacizumab | Regorafenib | Sunitinib | Nintedanib | Semaxinib | Cabozantinib | Ponatinib | Axitinib | Midostaurin | Chloramphenicol | Pazopanib | Glycine | PD173074 | Tanshinone IIA | Fruquintinib | 5Z-7-Oxozeaenol | Vandetanib | SU 5402 | Linifanib | Foretinib | SPHINX31 | Ripretinib | GW806742X | Dovitinib 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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