Eupatilin | 异泽兰黄素 | MedChemExpress (MCE)

Eupatilin 产品活性：Eupatilin 是从艾叶中分到的亲脂性黄酮类化合物，是 PPARα 的激动剂，具有抗凋亡，抗氧化及抗炎等功效。 产品来源： https://www.medchemexpress.cn/Eupatilin.html 研究领域：Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor | Metabolic Enzyme/Protease | Autophagy 作用靶点：PPAR | Autophagy 来源：植物 | 豆科 | 苏门答腊油楠 | 植物 | 菊科 结构分类：黄酮类 | 黄酮 | 结构分类 In Vitro: Eupatilin is a PPARα agonist. Eupatilin (10, 30, 100 μM) suppresses IL-4 expression and degranulation in RBL-2H3 cells. Eupatilin (50-100 μM) slightly reduces cell viability of HaCaT cells. Eupatilin (10, 30, 50, 100 μM) increases PPARα transactivation and expression in HaCaT cells. Eupatilin (10, 30, 50 μM) also suppresses TNFα-induced MMP-2/-9 expression in HaCaT cells. Furthermore, Eupatilin inhibits TNFα-induced p65 translocation, IκBα Phosphorylation, AP-1 and MAPK signaling via PPARα. Eupatilin (10-50 μM) shows no cytotoxic effects on ARPE19 cells. Eupatilin (10, 25, 50 μM) elevates cell viability from oxidative stress, and inhibits H2O2-induced ROS production in ARPE19 cells. Moreover, Eupatilin (50 μM) inbibits H2O2-induced cells apoptosis and promotes the activation of PI3K/Akt pathway in RPE cells. In Vivo: Eupatilin (1.5% or 3.0%) restores PPARα mRNA expression, and improves atopic dermatitis (AD)-like symptoms in oxazolone-induced Balb/c mice. Eupatilin causes significant decrease in serum IgE, IL-4 levels, oxazolone-induced TNFα, IFNγ, IL-1β, TSLP, IL-33 and IL-25 mRNA expression in oxazolone-induced mice. Eupatilin also increases filaggrin and loricrin mRNA expression in oxazolone-induced mice. 相关产品：Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Natural Product Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Medicine Food Homology Compound Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Flavonoids Library | Transcription Factor-Targeted Library | Lipid Metabolism Compound Library | Food-Sourced Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Nuclear Receptor Compound Library | Non-steroidal Anti-Inflammatory Compound Library | Off-patent Drug Library | Mitochondrial Protection Compound Library | Metabolic Enzyme Compound Library | Highly Selective Activators Library | Cell Death Library | FDA-Approved Traditional Chinese Medicine Active Compound Library | Bioactive Compound Library Max | Retinoic acid | Rosiglitazone | GW9662 | Pioglitazone | GW6471 | Fenofibrate | Fisetin | Pirinixic acid | T0070907 | 5-Aminosalicylic Acid | Troglitazone | Daidzein | Astaxanthin | Icariin | GW 501516 | Gemfibrozil 1-O-β-glucuronide | GW7647 | Lanifibranor | Bezafibrate | GW1929 | Elafibranor | Glabridin | Fucoxanthin | GW0742 | MK-886 | GSK0660 | GSK3787 | Magnolol | AZD-9574 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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