Agrimol B | 仙鹤草酚 B | MedChemExpress (MCE)

Agrimol B 产品活性：Agrimol B 是一种多酚，是一种口服有效的 SIRT1 激活剂。Agrimol B 具有抗成脂 (anti-adipogenic) 和抗肿瘤 (anticancer) 活性。Agrimol B 对植物病原菌具有抗菌 (antibacterial) 活性。Agrimol B 通过降低 PPARγ、C/EBPα、FAS、UCP-1 和 apoE 表达，显著抑制 3T3-L1 脂肪细胞分化。Agrimol B 对癌细胞的作用可能源于其对 c-MYC、SKP2 和 p27 的作用。 产品来源： https://www.medchemexpress.cn/agrimol-b.html 研究领域：Cell Cycle/DNA Damage | Epigenetics | Metabolic Enzyme/Protease | Vitamin D Related/Nuclear Receptor | Apoptosis | Anti-infection 作用靶点：Sirtuin | PPAR | Fatty Acid Synthase (FASN) | c-Myc | Bacterial 来源：植物 | 蔷薇科 | 龙牙草 结构分类：酚类 | 多酚类 | 结构分类 In Vitro: Agrimol B blocks adipogenesis at the early stage of differentiation in a dose-dependent manner, with an IC50 of 3.35 ± 0.32 μM.? Agrimol B induces SIRT1 (silent information regulator 2 homolog 1) translocation and expression in 3T3-L1 adipocytes.? Agrimol B inhibits PC-3 and A549 cells growth, with GI50 (growth inhibition 50%) values of 29 and 19 μM, GI75 values of 49 and 50 μM, and GI90 values of 63 and 76 μM, respectively.? Agrimol B (0-76 μM) dose-dependently increases cells at G0 in both cell lines.? Agrimol B (0-76 μM, 3 days) reduces the protein expression of c-MYC and SKP2 (S-phase kinase-associated protein 2), increases p27 (cyclin-dependent kinase inhibitor 1B), and down-regulates SPT16 (Suppressor of Ty Homolog-16) and SSRP1 (Structure-Specific Recognition Protein 1). In Vivo: Agrimol B (10 mg/kg, Orally, daily) reduces growth of prostate cancer cell xenograft in mice. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Oxygen Sensing Compound Library | Antibacterial Compound Library | Phenols Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Lipid Metabolism Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Anti-Prostate Cancer Compound Library | Nuclear Receptor Compound Library | Osteogenesis Compound Library | Cancer Stem Cells Compound Library | Mitochondrial Protection Compound Library | Metabolic Enzyme Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Rapamycin | Doxorubicin hydrochloride | Bafilomycin A1 | Dimethyl sulfoxide | Dexamethasone | Puromycin dihydrochloride | Staurosporine | Actinomycin D | Retinoic acid | Etoposide | G-418 disulfate | Nigericin sodium salt | 5-Azacytidine | Brefeldin A | CCCP | Estradiol | Rosiglitazone | Nicotinamide | Ionomycin | Hygromycin B | Mitomycin C | Resveratrol | Tunicamycin | Everolimus | Doxycycline hyclate | Tacrolimus | Selisistat | Methotrexate | GW9662 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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