Lactacystin | 蛋白酶体抑制剂 | MedChemExpress (MCE)

Lactacystin 产品活性：Lactacystin 是一种有效的、口服活性、不可逆的、细胞渗透性的，选择性的 20S 蛋白酶体 (proteasome) 抑制剂 (IC50 = 4.8 μM)。Lactacystin 还能抑制溶酶体酶组织蛋白酶 A (cathepsin A)。Lactacystin 抑制细胞生长，诱导细胞凋亡 (apoptosis) 和周期阻滞，并具有抗病毒和抗氧化活性。Lactacystin 诱导神经突生长，诱发高血压。Lactacystin 在癌症、神经系统疾病、高血压和疟疾等方面具有研究潜力。 产品来源： https://www.medchemexpress.cn/lactacystin.html 研究领域：Metabolic Enzyme/Protease | Apoptosis | Protein Tyrosine Kinase/RTK 作用靶点：Proteasome | Apoptosis | ROS Kinase 结构分类：抗生素 | 其他类 | 结构分类 In Vitro: Lactacystin (up to 25.6 µM, 1 h) has no cytotoxicity to HeLa or SH-SY5Y cells, and decreases RVP infection by 63.8% in HeLa and by 74.5% in SH-SY5Y cells. Lactacystin (2.5 μM) in combination with Parthenolide (HY-N0141) (5 μM) causes a synergistic increase in the apoptotic fraction of the drug-resistant L1210 cells. Lactacystin（2.5, 5 and 10  µM, 24 h）inhibits the proliferation (IC50 value of 10 μ M) and increases the apoptotic in C6 cells. Lactacystin (10μM, 24 h) increases Cisplatin (HY-17394)-induced ER stress-associated apoptosis in Hela cells. Lactacystin (7.5 μM, 4-48 h) increased reactive oxygen species and GSH levels in HT-29 cells. Lactacystin (1, 2.5, 5 μM, 24 h) induces stellation in astrocytes from neonatal rat cortex. Lactacystin (10μM, 8-24 h) induces apoptosis, G2/M cell cycle arrest in the PC12 cells. In Vivo: Lactacystin (2 μg for ICV) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice. Lactacystin (1.0 ug or 5.0  µg/20g for 7days) results in significantly smaller tumor and promotes apoptosis than control in C6 orthotopic xenograft tumor models. Lactacystin (5 mg/kg/day, dissolved in drinking water, six weeks) induces model of hypertension in male adult Wistar rats. 相关产品：MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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