Rifamycin S | 利福霉素S | MedChemExpress (MCE)

Rifamycin S 产品活性：Rifamycin S 是一种醌和抗革兰氏阳性细菌 (包括 MRSA) 的抗生素。Rifamycin S 是涉及两个电子的可逆氧化还原系统的氧化形式。Rifamycin S 可以产生活性氧 (ROS) 并抑制微粒体脂质过氧化，并可用于肺结核和麻风病的研究。 产品来源： https://www.medchemexpress.cn/rifamycin-s.html 研究领域：Anti-infection | Metabolic Enzyme/Protease | Immunology/Inflammation | NF-κB 作用靶点：Bacterial | Reactive Oxygen Species | Antibiotic 结构分类：醌类 | 萘醌类 | 酚类 | 单酚类 | 结构分类 In Vitro: The inhibition of bacterial growth by Rifamycin SV is due to the production of active species of oxygen resulting from the oxidation-reduction cycle of Rifamycin SV in the cells. The aerobic oxidation of Rifamycin SV to Rifamycin S is induced by metal ions, such as Mn2+, Cu2+, and Co2+. The most effective metal ion is Mn2+. In Vivo: Rat liver sub-mitochondrial particles also generated hydroxyl radical in the presence of NADH and Rifamycin S. NADH dehydrogenase (complex I) as the major component involved in the reduction of Rifamycin S. Compared to NADPH, NADH is almost as effective (Rifamycin S) in catalyzing the interactions of these antibiotics with rat liver microsomes. Rifamycin S is shown to be readily reduced to Rifamycin SV, the corresponding hydroquinone by Fe(II). Rifamycin S forms a detectable Fe(II)-(Rifamycin S)3 complex. The Fe:ATP induced lipid peroxidation is completely inhibited by Rifamycin S. Rifamycin S can interact with rat liver microsomes to undergo redox-cycling, with the subsequent production of hydroxyl radicals when iron complexes are present. 相关产品：Covalent Screening Library Plus | Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Aging Compound Library | Covalent Screening Library | Antioxidant Compound Library | Macrocyclic Compound Library | Oxygen Sensing Compound Library | Antibacterial Compound Library | Ferroptosis Compound Library | Phenols Library | Pyroptosis Compound Library | FDA Approved & Pharmacopeial Drug Library | Antibiotics Library | Microbial Metabolite Library | Mitochondria-Targeted Compound Library | Anti-tuberculosis Compound Library | Metabolic Enzyme Compound Library | Anti-Ovarian Cancer Compound Library | Radioprotector Library | Mitophagy Compound Library | Bioactive Compound Library Max | Rapamycin | Cycloheximide | Chloroquine | Doxorubicin hydrochloride | Bafilomycin A1 | Dimethyl sulfoxide | Dexamethasone | Acetylcysteine | H2DCFDA | Puromycin dihydrochloride | Staurosporine | Actinomycin D | Deferoxamine mesylate | MitoSOX Red | Etoposide | Elesclomol | G-418 disulfate | Nigericin sodium salt | Cyclosporin A | 5-Azacytidine | Brefeldin A | CCCP | Estradiol | Quercetin | Bleomycin sulfate | Ionomycin | Hygromycin B | Mitomycin C | L-Ascorbic acid | Resveratrol 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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