Orexin A (human, rat, mouse) (acetate) | MedChemExpress (MCE)

Orexin A (human, rat, mouse) (acetate) 产品活性：Orexin A (Hypocretin-1) (human, rat, mouse) acetate 是一种具有镇痛特性的下丘脑神经肽 (可透过血脑屏障)。Orexin A (human, rat, mouse) acetate 也是一种 OX1R 激动剂，能以时间和剂量依赖性的方式诱导 SH-SY5Y 细胞 BDNF 和 TH 蛋白的表达。Orexin A (human, rat, mouse) acetate 可用于食欲调节、神经退行性疾病，以及调节伤害性信息传递的研究。 产品来源： https://www.medchemexpress.cn/orexin-a-human-rat-mouse-acetate.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：Orexin Receptor (OX Receptor) In Vitro: Orexin A (human, rat, mouse) acetate (0.1, 1, 10, 100 nM; 24 h) increases the expression of BDNF in SH-SY5Y human dopaminergic neuroblastoma cells in a dose-dependent manner. Orexin A (human, rat, mouse) acetate (1 nM; 1, 3, 6, 12, 24 h) increases the expression of BDNF, TH, and PI3K in a time-dependent manner in SH-SY5Y cells. In Vivo: Orexin A (human, rat, mouse) acetate (300 ng/mouse; i.c.v.; single daily for 8 days) attenuates the loss of dopaminergic neurons and the decrease of tyrosine hydroxylase (TH) expression in the substantia nigra, normalized the striatal dopaminergic fibers, and prevents the depletion of dopamine and its metabolites in the striatum. Orexin A (human, rat, mouse) acetate (10, 30 mg/kg; i.v.; single) shows to be analgesic in the carrageenan-induced thermal hyperalgesia model and PPQ-induced mouse abdominal constriction model. 相关产品：Bioactive Compound Library Plus | Peptide Library | Orexin A (human, rat, mouse) (TFA) | Danavorexton | Almorexant | SB-334867 free base | YNT-185 dihydrochloride | Seltorexant | EMPA | JNJ-10397049 | Orexin 2 Receptor Agonist | SB-674042 | Filorexant | Orexin B, human TFA | SB-649868 | MK-1064 | OXA(17-33) | TCS 1102 | TCS-OX2-29 | Cudarolimab | ACT-462206 | GSK1059865 | Revdofilimab | Firazorexton | Orexin B, rat, mouse | RTIOXA-43 | SB-408124 | Vornorexant 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途