TAK-901 | MedChemExpress (MCE)

TAK-901 产品活性：TAK-901是多靶点的的极光激酶 (aurora)抑制剂，对极光激酶A和B的IC50 值分别为21 和15 nM。 产品来源： https://www.medchemexpress.cn/TAK-901.html 研究领域：Cell Cycle/DNA Damage | Epigenetics 作用靶点：Aurora Kinase In Vitro: TAK-901 exhibits time-dependent, tight-binding inhibition of Aurora B, but not Aurora A. Consistent with Aurora B inhibition, TAK-901 suppresses cellular histone H3 phosphorylation and induces polyploidy. In various human cancer cell lines, TAK-901inhibits cell proliferation with effective concentration values from 40 to 500 nM. Examination of a broad panel of kinases in biochemical assays reveals inhibition of multiple kinases. However, TAK-901 potently inhibits only a few kinases other than Aurora B in intact cells, including FLT3 and FGFR2. In Vivo: In rodent xenografts, TAK-901 exhibits potent activity against multiple human solid tumor types, and complete regression is observed in the ovarian cancer A2780 model. TAK-901 also displayed potent activity against several leukemia models. TAK-901 induces pharmacodynamic responses consistent with Aurora B inhibition and correlating with retention of TAK-901 in tumor tissue. 相关产品：Clinical Compound Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Clinical Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Cytoskeleton Compound Library | Anti-Blood Cancer Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Serine/Threonine Kinase Inhibitor Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Alisertib | Barasertib-HQPA | Reversine | Tozasertib | Ceftriaxone sodium salt | JNJ-7706621 | AT9283 | Hesperadin | MK-5108 | KW-2449 | AMG 900 | GSK-1070916 | Danusertib | ZM-447439 | LY3295668 | PF-03814735 | Palmatine chloride | MLN8054 | TAK-632 | JB170 | BI-847325 | XL228 | SNS-314 mesylate | SP-96 | TCS7010 | CYC-116 | CCT 137690 | GW779439X | ENMD-2076 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

TAK-901 | MedChemExpress (MCE)信息由MedChemExpress (MCE)为您提供，如您想了解更多关于TAK-901 | MedChemExpress (MCE)报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途