Reversine | 逆转素 | MedChemExpress (MCE)

Reversine 产品活性：Reversine 是一种ATP-竞争性的 Aurora kinase 抑制剂，作用于 Aurora A，Aurora B 和 Aurora C，IC50 分别为 400，500 和 400 nM。 产品来源： https://www.medchemexpress.cn/reversine.html 研究领域：Cell Cycle/DNA Damage | Epigenetics | Autophagy 作用靶点：Aurora Kinase | Autophagy In Vitro: Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Reversine is a potent inhibitor of Aurora A and B and is also an inhibitor of Aurora C kinase. Aurora A and B activities are inhibited by 80% and Aurora kinase C by 55%, already at a concentration of 0.5 μM, whereas no inhibition or only modest inhibition is observed on others kinases tested. In a second round of experiments, the IC50 of Reversine is determined on Aurora kinase A to be 400 nM, whereas Aurora kinase B and C IC50 are 500 and 400 nM, respectively. The IC50 is also determined on MEK1 is >1.5 μM and that the IC50 on muscle myosin (an analogue of nonmuscle myosin II) is 350 nM. In Vivo: The combination of Reversine and Aspirin can more efficiently induce cell cycle arrest and apoptosis. To evaluate the anti-tumor effect of this combination, a xenograft nude mouse model is established by s.c. injection. Mice inoculated with cervical cancer cells have lost about 10 % of their initial body weight by about 16 days after tumor inoculation. However, tumor growth (tumor weight) is reduced and the mice survive longer in the combination group. 相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Cytoskeleton Compound Library | Anti-Blood Cancer Compound Library | Membrane Protein-targeted Compound Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | Anti-Hematopathy Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Alisertib | Barasertib-HQPA | Tozasertib | Ceftriaxone sodium salt | JNJ-7706621 | AT9283 | Hesperadin | MK-5108 | KW-2449 | AMG 900 | GSK-1070916 | Danusertib | ZM-447439 | LY3295668 | PF-03814735 | Palmatine chloride | MLN8054 | TAK-632 | JB170 | BI-847325 | TAK-901 | XL228 | SNS-314 mesylate | SP-96 | TCS7010 | CYC-116 | CCT 137690 | GW779439X | ENMD-2076 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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