Aprocitentan | MedChemExpress (MCE)

Aprocitentan 产品活性：Aprocitentan (ACT-132577) 是 Macitentan 的主要活性代谢物。Aprocitentan 是双重 ETA/ETB 拮抗剂，IC50 分别为 3.4 nM 和 987 nM，pA2 值分别为 6.7 和 5.5。 产品来源： https://www.medchemexpress.cn/ACT-132577.html 研究领域：GPCR/G Protein 作用靶点：Endothelin Receptor In Vitro: Aprocitentan (ACT-132577) achieves full inhibition of intracellular calcium increase induced by ET-1 on nonrecombinant cells (primary human pulmonary smooth muscle cells and rat aortic smooth muscle cell line A10 and mouse fibroblast cell line 3T3). In Vivo: Aprocitentan (ACT-132577) has a volume of distribution greater than the plasma volume and a longer half-life than its parent compound in the rat. In rat plasma, the mean recovery of Aprocitentan (ACT-132577) ranges from 82.6% to 90.6%, matrix effect of Aprocitentan (ACT-132577) in rat plasma ranges from 101.4% to 115.2%. 相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Endocrinology Compound Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Angiogenesis-Related Compound Library | Targeted Diversity Library | Coagulation and Anti-coagulation Compound Library | Pain-Related Compound Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Multi-Target Compound Library | Bioactive Compound Library Max | Endothelin 1 (swine, human) | Bosentan | Macitentan | Ambrisentan | BQ-788 | Atrasentan hydrochloride | BQ-123 | Carperitide acetate | Endothelin-3, human, mouse, rabbit, rat TFA | Atrial Natriuretic Peptide (ANP) (1-28), rat | Sulfisoxazole | Sitaxsentan sodium | Sparsentan | Zibotentan | Clazosentan | A-192621 | IRL-1620 TFA | Nebentan potassium | Darusentan | IRL 2500 | Tezosentan | Avosentan | Ro 46-8443 | BMS 182874 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途