GW274150 | MedChemExpress (MCE)

GW274150 产品活性：GW274150 是一种有效的，选择性的，口服活性的 NADPH 依赖型人一氧化氮合成酶 (iNOS) (Kd=40 nM) 和大鼠诱导型一氧化氮合酶 (iNOS) 抑制剂。GW274150 对人和大鼠的内皮一氧化氮合酶 (eNOS) 和神经元一氧化氮合酶 (nNOS) 均显示较低效力。GW274150 在急性肺损伤炎症模型中发挥保护作用。 产品来源： https://www.medchemexpress.cn/GW274150.html 研究领域：Immunology/Inflammation 作用靶点：NO Synthase In Vitro: GW274150 inhibits intracellular iNOS in J774 cells in a time-dependent manner, reaching IC50 values of 0.2 μM.GW274150 is >260-fold and 219-fold selective for iNOS against eNOS and nNOS in rat tissues, respectively. And it displays >100-fold and >80-fold for human iNOS against human eNOS and nNOS, respectively. In Vivo: GW274150 is a long-acting (5 h half‐life in rats) iNOS inhibitor and is able to inhibit LPS‐mediated increase in plasma NO2-, NO3- levels 14 h after single intraperitoneal dose (ED50=3 mg/kg).GW274150 (intraperitoneal injection; 2.5, 5, and 10 mg/kg; before carrageenan injection) reduces the degree of lung injury induced by carrageenan in a dose-related fashion. Oedema formation and PMNs infiltration in the pleural cavity are also significantly attenuated in a dose‐related manner in rats.GW274150 (oral adminstration; 30 mg/kg; twice daily; 7 days) leads to significant neuroprotection, However, it displays a bell-shaped neuroprotective profile, being ineffective at high doses in 6-OHDA rat model of Parkinson disease (PD). 相关产品：L-NAME hydrochloride | Mifepristone | Midostaurin | L-Arginine | DMPO | S-Nitroso-N-acetyl-DL-penicillamine | 1400W Dihydrochloride | DETA NONOate | Human serum albumin | Isoquercetin | Ethacrynic acid | Methylene Blue | Fucoxanthin | L-NMMA acetate | Chondroitin sulfate | Tetrahydrobiopterin | PRE-084 hydrochloride | 2,4-Diamino-6-hydroxypyrimidine | L-NIL | Aminoguanidine hydrochloride | Lipoamide | Asymmetric dimethylarginine | Carboxy-PTIO potassium | Avanafil | Prim-O-glucosylcimifugin | Agmatine sulfate | Ginsenoside C-K | 6-Biopterin | Tryptanthrin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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