GNE-3511 | MedChemExpress (MCE)

GNE-3511 产品活性：GNE-3511 是一种生物可利用性和脑渗透 dual leucine zipper kinase (DLK) 抑制剂，具有口服活性，其 Ki 值为 0.5 nM。GNE-3511 可穿过血脑屏障，被用于神经退行性疾病的研究。 产品来源： https://www.medchemexpress.cn/GNE-3511.html 研究领域：MAPK/ERK Pathway 作用靶点：MAP3K In Vitro: GNE-3511 has inhibitory activity for p-JNK and DRG with IC50 values of 30 nM and 107 nM, respectively. GNE-3511 has kinase selectivity for MKK4, MKK7, JNK1, JNK2, JNK3, MLK1, MLK2 and MLK3 with IC50 values of ＞5000 nM, ＞5000 nM, 129 nM, 514 nM, 364 nM, 67.8 nM, 767 nM and 602 nM, respectively. GNE-3511 displays concentration-dependent protection of neurons from degeneration in vitro. In Vivo: GNE-3511 (oral gavage; 75 mg/kg; single) suppresses CYP-induced nociceptive behavior by inhibiting DLK in mice. GNE-3511 (oral gavage; 75 mg/kg; single) suppresses CYP-induced edema and hemorrhage in mouse bladder. GNE-3511 (iv.; 1 mg/kg or po.; 5 mg/kg) exhibits moderate in vivo plasma clearances, moderate volumes of distribution, short half-lives, and brain penetration. Pharmacokinetic Parameters of GNE-3511 (iv.; 1 mg/kg or po.; 5 mg/kg). species CLp (mL/min/kg Vdss (L/kg t1/2 (h) F (%) Bu/Pu CSF/Pu mouse 56 2.5 0.6 45 0.24 at 6 h rat 30 3.7 1.8 63 0.7 0.4 dog 41 6.5 4 32 0.4 cynomolgous 16 3.1 2.4 19 0.6 相关产品：Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | CNS-Penetrant Compound Library | Oxygen Sensing Compound Library | Orally Active Compound Library | Chemical Probe Library | Neurodegenerative Disease-related Compound Library | Anti-Obesity Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Serine/Threonine Kinase Inhibitor Library | Bioactive Compound Library Max | Takinib | 5Z-7-Oxozeaenol | Selonsertib | TAO Kinase inhibitor 1 | SM1-71 | Cot inhibitor-2 | GS-444217 | Tpl2 Kinase Inhibitor 1 | NG25 | 7,3',4'-Trihydroxyisoflavone | NQDI-1 | TAK1-IN-2 | PF-05381941 | Cot inhibitor-1 | TAK1/MAP4K2 inhibitor 1 | TAK1-IN-3 | ASK1-IN-2 | DLK-IN-1 | GNE-8505 | TAK1-IN-4 | TC ASK 10 | ASK1-IN-3 | ASK1-IN-4 | ASK1-IN-5 | AZ-TAK1 | DDO3711 | IACS-52825 | JT21-25 | N-Acetylgalactosaminyltransferase 4 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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