Ethosuximide | 乙琥胺 | MedChemExpress (MCE)

Ethosuximide 产品活性：Ethosuximide 是一种广泛使用的抗癫痫活性分子，可改善多种神经退行性疾病模型的表型，且可阻断低电压激活的 T 型钙通道。 产品来源： https://www.medchemexpress.cn/Ethosuximide.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling 作用靶点：Calcium Channel In Vitro: The efficacy of Ethosuximide in generalized absence epilepsy is thought to be due to blockade of the low voltage activated T-type calcium channel. There is no reduction in total Tau levels in Ethosuximide treated Tau transgenic worms as compare to vehicle controls. The rescuing effect of Ethosuximide is therefore not due to transgene suppression or reduced expression of toxic mutant Tau protein. Quantification of the amount of soluble and insoluble (RIPA-extractable) Tau relative to total Tau levels reveals a significant reduction in aberrantly-folded, insoluble Tau and a corresponding increase in soluble Tau in Ethosuximide-treated compare with untreated worms. Concentrations of 2 μM or more of Ethosuximide not only are found to be less effective than 1 μM concentration of Ethosuximide, but also induce cell toxicity. GABA staining immuno uorescence images show that after treatment with Ethosuximide, GABA positive neuron increases by 3 and 6.5 fold for concentrations of 0.1 and 1 μM, respectively. BrdU staining shows nuclei proliferation after 2 to 3 days of Ethosuximide exposure. The mean of nuclei is 15.98±0.41 for the low concentration of Ethosuximide while it is 25.27±0.48 for the high concentration after Brdu staining. This number is 11.05±0.2 for lithium chloride. 相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | CNS-Penetrant Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Neuroprotective Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Children’s Drug Library | Calcium Channel Blocker Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Anti-Aging Natural Product Library | Pain-Related Compound Library | Off-patent Drug Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Ion Channel Compound Library | Bioactive Compound Library Max | Thapsigargin | Ionomycin | L-Ascorbic acid | Minocycline hydrochloride | Verapamil | 2-Aminoethyl diphenylborinate | Acetylcholine chloride | GSK1016790A | Nifedipine | Fasudil Hydrochloride | Ebselen | Halofuginone | Bay K 8644 | Carbamazepine | Tetrandrine | Ruthenium red | L-Phenylalanine | ISX-9 | Gabapentin | Amlodipine | CDN1163 | TPC2-A1-N | Ethacrynic acid | Cromolyn sodium | Dantrolene | Diltiazem hydrochloride | Taurolithocholic acid sodium salt 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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