Ferrostatin-1 | MedChemExpress (MCE)

Ferrostatin-1 产品活性：Ferrostatin-1 (Fer-1) 是一种有效的、选择性的 ferroptosis 抑制剂，抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 是一种人工合成的抗氧化剂，通过还原机制来防止膜脂的损伤，从而抑制细胞死亡。Ferrostatin-1 具有抗真菌活性。 产品来源： https://www.medchemexpress.cn/Ferrostatin-1.html 研究领域：Apoptosis | Anti-infection 作用靶点：Ferroptosis | Fungal In Vitro: Ferrostatin-1 prevents erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 prevents glutamate-induced neurotoxicity in organotypic rat brain slices. Ferrostatin-1 (2 μM; 24 h) prevents Glutamate (5 mM)-induced neurotoxicity in a rat organotypic hippocampal slice culture (OHSC). Ferrostatin-1 inhibits lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction. Ferrostatin-1 (1 μM; 6 h) inhibits the oxidative destruction of unsaturated fatty acids in HT-1080 cells, thus increases the number of healthy medium spiny neurons (MSNs). In Vivo: Ferrostatin-1 (5 mg/kg; ip; single dose, 30 min before glycerol injection) improves renal function in mice with rhabdomyolysis, whereas no beneficial effects were observed with the pan-caspase inhibitor zVAD or in RIPK3-deficient mice. Ferrostatin-1 (0.8 mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI). Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis. Ferrostatin-1 (10 mg/kg/d, i.p., 3 d) attenuates hypoxic-ischemic brain damage-, oxygen-glucose deprivation-, or Erastin (HY-15763)-induced ferroptosis in brain of neonatal rats. Ferrostatin-1 (0.655 mg/kg, i.p., 3 times a week for 6 week) exerts anti-ferroptosis effects by increasing GPX4 activity and by inhibiting lipid peroxidation in the salivary gland of ovariectomized (postmenopausal model) rats. 相关产品：Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Anti-Cancer Compound Library | Antioxidant Compound Library | Antifungal Compound Library | Ferroptosis Compound Library | Highly Selective Inhibitors Library | Cell Death Library | Radioprotector Library | Bioactive Compound Library Max | Rapamycin | Erastin | Cisplatin | Cycloheximide | RSL3 | Acetylcysteine | Staurosporine | ML385 | Sorafenib | Necrostatin-1 | SP600125 | Rosiglitazone | Liproxstatin-1 | Hygromycin B | Resveratrol | Tunicamycin | Curcumin | Oligomycin | Simvastatin | Camptothecin | Acetaminophen | Hemin | L-Glutathione reduced | TBHQ | Trolox | Roxadustat | Lapatinib | Lovastatin | Sulfasalazine | NADPH tetrasodium salt 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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