KY-226 | MedChemExpress (MCE)

KY-226 产品活性：KY-226 是一种有效的，选择性的，口服活性的和变构蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，IC50 为 0.25 μM，且不激活 PPARγ 。KY-226 通过增强胰岛素和瘦素信号传导发挥抗糖尿病和抗肥胖作用。KY-226 还可以保护神经元免受脑缺血损伤。 产品来源： https://www.medchemexpress.cn/ky-226.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Phosphatase In Vitro: In human hepatoma-derived cells (HepG2), KY-226 (0.3-10 μM) increases the phosphorylated insulin receptor (pIR) produced by insulin. KY-226 (1 μM; 24 hours; bEnd.3 cells) treatment rescues lipopolysaccharide-induced reduction of mRNA and protein levels of ZO-1. KY-226 treatment restores phosphorylation of pAkt (T308) and its downstream target forkhead box protein O1 (FoxO1) (S256) in bEnd.3 cells. In Vivo: KY-226 (10-30 mg/kg/day; oral administration; daily; for 4 weeks; male db/db mice) treatment significantly reduces plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain. KY-226 attenuates plasma glucose elevations in the oral glucose tolerance test. KY-226 also increases pIR and phosphorylated Akt in the liver and femoral muscle. 相关产品：Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-diabetic Compound Library | Orally Active Compound Library | Phosphatase Inhibitor Library | Anti-Obesity Compound Library | Metabolic Enzyme Compound Library | Highly Selective Inhibitors Library | Bioactive Compound Library Max | Cyclosporin A | Tacrolimus | SHP099 | Calyculin A | β-Glycerophosphate disodium salt pentahydrate | Okadaic acid | Salubrinal | Sodium orthovanadate | Ebselen | Batoprotafib | L-Ascorbic acid 2-phosphate trisodium | Suramin sodium salt | Osunprotafib | RMC-4550 | TPI-1 | GSK 2830371 | Sodium metatungstate | DT-061 | SF1670 | Vociprotafib | NSC 663284 | Idoxuridine | D-erythro-Sphingosine | MSI-1436 lactate | BCI | LB-100 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途