Upidosin | MedChemExpress (MCE)

Upidosin 产品活性：Upidosin (Rec 15/2739) 是 α-1 肾上腺素受体 (α-1 AR) 拮抗剂。Upidosin 具有对 α-1A AR 亚型的中等选择性。Upidosin 具有尿选择性，在尿道和前列腺有更高的亲和力，Kb 值为 2-3 nM，在耳动脉和主动脉的 Kb 值为 20-100 nM。Upidosin 抑制 [3H]prazosin 与人 α-1A 肾上腺素受体结合。Upidosin 可用于尿道梗阻的研究。 产品来源： https://www.medchemexpress.cn/upidosin.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：Adrenergic Receptor In Vitro: Upidosin is one of the most potent compounds action on the prostate with comparing the apparent pKB values, but its potency is slightly lower than that of tamsulosin and is higher than the potencies of prazosin, terazosin and 5-methylurapidil. Upidosin shows binding affinities to cloned humanα1A, humanα1B, humanα1D adrenoceptors with pKi value of 9.0, 7.5 and 8.6, respectively. In Vivo: Upidosin shows greater selectivity than any other α-1 AR antagonist terazosin and tamsulosin in the anesthetized dog. Upidosin (1-300 μg/kg; i.v.) is a more potent antagonist of phenylephrine mediated increases in prostatic pressure with a pA2 value of 8.74 compared to blood pressure with a pA2 value of 7.51. 相关产品：Natural Product-like Compound Library | Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Neuronal Signaling Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Neurotransmitter Receptor Compound Library | Anti-Alzheimer's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Antidepressant Compound Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Bioactive Compound Library Max | Isoprenaline hydrochloride | Norepinephrine | Zenidolol hydrochloride | Propranolol hydrochloride | Phenylephrine | CL 316243 | D-Mannitol | Metoprolol | L-Epinephrine | Atenolol | Carvedilol | Pimozide | Clozapine | Prazosin hydrochloride | Olanzapine | Dexmedetomidine | Nadolol | Amitriptyline hydrochloride | Mirabegron | Yohimbine | Phenylacetylglycine | Brexpiprazole | Salbutamol | Salmeterol | 2',5'-Dideoxyadenosine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途