SRT 1720 dihydrochloride | MedChemExpress (MCE)

SRT 1720 dihydrochloride 产品活性：SRT 1720 dihydrochloride 是选择性的和具有口服活性的 SIRT1 激活剂，EC50 为 0.10 μM，对 SIRT2 和 SIRT3 的作用较弱。 产品来源： https://www.medchemexpress.cn/srt-1720-dihydrochloride.html 研究领域：Cell Cycle/DNA Damage | Epigenetics | Autophagy 作用靶点：Sirtuin | Autophagy In Vitro: SRT 1720 dihydrochloride effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300. In Vivo: SRT 1720 (10, 30, 100 mg/kg, p.o.) dihydrochloride treatment significantly reduces fasting blood glucose to near normal levels in Lepob/ob mice. SRT 1720 dihydrochloride has ability to protect against the negative effects of diet-induced obesity in mice, and has a connection to metabolic adaptation in fatty acid and oxidative metabolism through downstream targets of SIRT1 such as PGC1α and FOXO1. SRT 1720 (50-100 mg/kg, p.o.) dihydrochloride, during emphysema development attenuates elastase-induced airspace enlargement and lung function impairment as well as reduces arterial oxygen saturation in WT mice. 相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Histone Modification Research Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Anti-diabetic Compound Library | Oxygen Sensing Compound Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Anti-Obesity Compound Library | Metabolic Enzyme Compound Library | Highly Selective Activators Library | Cell Death Library | Radioprotector Library | Bioactive Compound Library Max | Nicotinamide | Resveratrol | Selisistat | Nicotinamide riboside chloride | 3-TYP | Fisetin | SRT 1720 | Suramin sodium salt | OSS_128167 | AGK2 | SRT 2104 | Sirtinol | UBCS039 | SIRT7 inhibitor 97491 | Thiomyristoyl | MC3482 | SirReal2 | Tenovin-6 | ADTL-SA1215 | Agrimol B | AK-7 | Cambinol | SRT 2183 | SRT 1460 | SIRT5 inhibitor 1 | SIRT6 activator 12q | CAY10602 | Ganoderic acid D | Perindopril erbumine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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