IT-901 | MedChemExpress (MCE)

IT-901 产品活性：IT-901 是一种具有口服活性且有效的 NF-κB 亚基 c-Rel 抑制剂，对 NF-κB 和 c-Rel 与 DNA 结合的 IC50 分别为 0.1 µM，3 μM。IT-901 是一种具有生物活性的萘硫代巴比妥酸酯衍生物，具有用于人类淋巴瘤和改善移植物抗宿主病 (GVHD) 的潜力。 产品来源： https://www.medchemexpress.cn/it-901.html 研究领域：NF-κB 作用靶点：NF-κB In Vitro: IT-901 (1, 3, 5 μM; for 24 hours) results in decreased proliferation of viable ABC and GCB DLBCL cells. IT-901 (3 μM; for 24 hours) decreases cell viability in a dose-dependent fashion, at least 60 percent of cells were still viable after 48 hours of IT-901 treatment (4μM) in all tested cell lines except HBL1. IT-901 (1, 5, 10 μM; for 6 hours) documents Diminished expression of p65 and p50 in nuclear and cytosolic fractions and also decreases the expression of the inhibitory subunit IκBα both in the phosphorylated and non-phosphorylated forms in primary CLL cells and cell lines. The IC50 of IT-901/GDM-12 is 2.9 μM for c-Rel whereas IL-2 secretion is successfully blocked at 5 μM. The concentrations of IT-901 above 10 μM become increasingly toxic and may lead to apoptosis of healthy cells. IT-901 inhibits cell growth of both activated B-like (ABC) and germinal center B-like (GCB) cell lines with the IC50 values between 3μM to 4μM. In Vivo: IT-901 (24 mg/kg; IP; every other day for 2 weeks) has an effective treatment of acute GVHD without impairing anti-tumor activity. IT-901 (12-20 mg/kg; IP) improves the PK profile by increasing T1/2 and Cmax. 相关产品：Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Pyroptosis Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Antidepressant Compound Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Pain-Related Compound Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Phorbol 12-myristate 13-acetate | Bortezomib | BAY 11-7082 | TAK-243 | JSH-23 | Shikonin | Sulfasalazine | Triptolide | Aspirin | Pyrrolidinedithiocarbamate ammonium | Baicalin | Dihydroartemisinin | 5-Aminosalicylic Acid | Parthenolide | CBL0137 hydrochloride | Isoginkgetin | BAY 11-7085 | Rocaglamide | Betulinic acid | SC75741 | Astaxanthin | Ergothioneine | QNZ | Andrographolide | SN50 | Nafamostat mesylate | 20(S)-Ginsenoside Rg3 | Hyperoside | Ginsenoside Rg1 | Lidocaine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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