Aliskiren hydrochloride | 盐酸阿利克仑半富马酸盐 d₆ | MedChemExpress (MCE)

Aliskiren hydrochloride 产品活性：Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride 是一种口服有效的、选择性的肾素 (renin) 抑制剂，IC50 为 1.5 nM。Aliskiren hydrochloride 可用于高血压、心血管疾病和癌症恶病质的研究。 产品来源： https://www.medchemexpress.cn/aliskiren-hydrochloride.html 研究领域：Metabolic Enzyme/Protease | Autophagy 作用靶点：Renin | Autophagy In Vitro: Aliskiren hydrochloride inhibits plasma renin activity (PRA) in vitro with IC50s of 2.9 nM (human PRA), 8.0 nM (monkey PRA), respectively. Aliskiren hydrochloride (10 μM; 24 h) inhibits prorenin-induced human aortic smooth muscle cell migration. Aliskiren hydrochloride (1-10 μM; 24 h) inhibits both the lamellipodia formation and morphological changes induced by prorenin with no significant effect on PDGF-BB activity. In Vivo: Aliskiren hydrochloride (3 mg/kg, 10 mg/kg; p.o.; daily; 0-12 d) inhibit renin and lower blood pressure without affecting heart rate in sodium-depleted marmosets. Aliskiren hydrochloride (10 mg/kg; p.o.; single dose) delays cachexia development, reduces tumor, and prolongs mouse survival. And also improves whole‑body strength, mobility and coordination, enhances locomotor activity, and inhibits muscle wasting. Aliskiren hydrochloride (10 mg/kg; p.o.; single dose; 20 d after C26 injection) reduces oxidative stress associated with cancer cachexia. 相关产品：Aliskiren | Araloside A | SPH3127 | Lyciumin A | VTP-27999 Hydrochloride | Bopindolol | PD 125967 | PD 132002 | PD 134922 | PD125754 | Remikiren | Renin inhibitor peptide,rat | Renin inhibitor-1 | Renin substrate 1 | Sodium new houttuyfonate | SQ 32970 | SR 42128 | Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC | Terlakiren | Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-Ome | ACT 178882 | Handle region peptide, rat 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途