5-Aminolevulinic acid hydrochloride (Standard) | 5-氨基乙酰丙酸盐酸盐 (标准品) | MedChemExpress (MCE)

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5-Aminolevulinic acid hydrochloride (Standard)

CAS No. : 5451-09-2

MCE 国际站：5-Aminolevulinic acid hydrochloride (Standard)

产品活性：5-Aminolevulinic acid (hydrochloride) (Standard) 是 5-Aminolevulinic acid (hydrochloride) 的分析标准品。本产品用于研究及分析应用。5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) 是体内血红素生物合成的中间体，为四吡咯的前体。

研究领域：Autophagy  |  Apoptosis  |  Metabolic Enzyme/Protease

作用靶点：Autophagy  |  Apoptosis  |  Endogenous Metabolite  |  Mitophagy

In Vitro: 5-Aminolevulinic acid hydrochloride (ALA) is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique.

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