CHIR-124-分析测试百科网

CHIR-124

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：5
近期咨询：0

分子式 C23H22ClN5O 分子量419.91 属性溶解性 DMSO 7 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 存贮条件储存温度-20°C //decorateTable('prod

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
C125171-100mg	405168-58-3	询底价
C125171-1mg	405168-58-3	询底价
C125171-25mg	405168-58-3	询底价
C125171-2mg	405168-58-3	询底价
C125171-5mg	405168-58-3	询底价

耗材描述

分子式 C₂₃H₂₂ClN₅O
分子量419.91

属性

溶解性	DMSO 7 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

备注	CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.
生化机理	CHIR-124 is a novel and potent chk1 inhibitor with an IC50 of 0.3 nM. Chk1 kinase is a critical regulator of both the S and G2/M phase cell cycle checkpoints in response to DNA damage. CHIR-124 has been shown that inhibitors of chk1 can selectively sensitize tumor cells with mutant p53 to genotoxic agents.
别名	(S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one;(S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one

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