耗材描述

• 分子式 C₁₄H₂₁N₃O·2HCl
• 分子量320.26
• MDL号 MFCD03490488
• PubChem编号 24277699

属性

溶解性	Soluble in water (14 mg/mL), ethanol (~5 mg/mL), DMSO (~20 mg/mL), DMF (~30 mg/mL), PBS, pH 7.2 (~10 mg/mL), and methanol (25 mg/mL).
存贮条件	储存温度-20°C

描述

应用	A cell permeable inhibitor of ROCK-1 and ROCK-2
产品介绍	Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2.
合法信息	Sold under license from Mitsubishi Pharma Corporation
备注	Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
生化机理	Y-27632 is ROCK inhibitor, as a novel bronchodilator. Y-27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively.
别名	(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride;ROCK Inhibitor;(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride;ROCK Inhibitor

标识符号	GHS07
信号词	Warning
危害声明	H302 + H312 + H332
警示性声明	P280
个人防护设备	dust mask type N95 (US), Eyeshields, Gloves
WGK德国	3

猜你喜欢

• 

  Obatoclax Mesylate

• 

  ABT-199 (GDC-0199)

• 

  PCI-24781 (Abexinostat)

• 

  MC1568

• 

  Dinaciclib (SCH727965)

• 

  NVP-LCQ195

• 

  ZM-447439

• 

  CCT241533

• 

  BI 2536

• 

  Hesperadin

感兴趣产品

• Y-27632 dihydrochloride价格
• Y-27632 dihydrochloride厂商
• Y-27632 dihydrochloride规格