Y129399-10mgY-27632 dihydrochloride
面议
- 阿拉丁
- 生产商
- Y129399-10mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C14H21N3O·2HCl
- 分子量320.26
- MDL号 MFCD03490488
- PubChem编号 24277699
属性
溶解性 | Soluble in water (14 mg/mL), ethanol (~5 mg/mL), DMSO (~20 mg/mL), DMF (~30 mg/mL), PBS, pH 7.2 (~10 mg/mL), and methanol (25 mg/mL). |
存贮条件 | 储存温度-20°C |
描述
应用 | A cell permeable inhibitor of ROCK-1 and ROCK-2 |
产品介绍 | Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2. |
合法信息 | Sold under license from Mitsubishi Pharma Corporation |
备注 | Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
生化机理 |
Y-27632 is ROCK inhibitor, as a novel bronchodilator. Y-27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively. |
别名 | (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride;ROCK Inhibitor;(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride;ROCK Inhibitor |
标识符号 | GHS07 |
信号词 | Warning |
危害声明 | H302 + H312 + H332 |
警示性声明 | P280 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
WGK德国 | 3 |
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