耗材描述

• 分子式 C₃₂H₄₈N₄O₈
• 分子量616.75
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

溶解性	Soluble in water, ethanol (10 mg/mL), and DMSO (>25 mg/mL).
存贮条件	储存温度-20°C

描述

应用	A synthetic Geldanamycin derivative and inhibitor of Hsp90.
产品介绍	Alvespimycin (17-DMAG; KOS-1022; NSC 707545)是水溶性HSP90抑制剂，IC50为62 nM。
生化机理	17-DMAG, 17-dimethylaminoethylamino-17-demethoxygeldanamycin, is a synthetic derivative of the antibiotic Geldanamycin with lower hepatotoxicity than the parent antibiotic and higher potency and availability than the similar derivative 17-AAG .17-DMAG is described to bind and inhibit the activity of Hsp90 (heat shock protein 90), a cellular chaperone that is over expressed in many cancers, and which participates in folding of proteins found in multiple signal transduction pathways.
别名	17-DMAG; KOS-1022; NSC 707545;阿螺旋霉素; 17-[2-(二甲基氨基)乙基氨基]-17-去甲氧基格尔德霉素;17-DMAG; KOS-1022; NSC 707545;17-Dimethylaminoethylamino-17-demethoxygeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin

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