| 应用 |
An inhibitor of HMGCR (HMG-CoA reductase). |
| 产品介绍 |
Fluvastatin Sodium抑制HMG-CoA reductase（HMG-CoA还原酶)活性，IC50为8 nM。 |
| 备注 |
Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM. |
| 生化机理 |
Fluvastatin, Sodium Salt is a synthetic inhibitor of HMGCR (HMG-CoA reductase) (IC50 = 40-100 nM for human liver microsomes) that acts as an anti-hypercholesterolemic compound and as an antioxidant. Fluvastatin also inhibits induction of the LDL receptor on HepG2 cells at a concentration of 0.1-1.0 μM. Research shows that fluvastatin can inhibit the formation of TBA-reactive substances in Fe(II)-supported peroxidation of liposomes (IC50 = 12 μM). |
| 别名 |
氟伐他汀钠; [R*,S*-(E)]-(+/-)-7-[3-(4-氟苯基)-1-(1-甲基乙基)-1-氢-吲哚-2-基]-3,5-二羟基庚-6-烯酸钠;Vastin;Leschol sodium;(3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid monosodium salt |
