Rolipram
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分子式 C16H21NO3 分子量275.34 Beilstein号 EC号 262-771-1 MDL号 MFCD00270906 PubChem编号 24278196 属性 熔点 130-134℃ 敏感性 对热敏感 溶解性 Solubl
| 货号 | CAS号 | 操作 |
|---|---|---|
| R129674-10mg | 61413-54-5 | 询底价 |
| R129674-50mg | 61413-54-5 | 询底价 |
| R129674-250mg | 61413-54-5 | 询底价 |
耗材描述
- 分子式 C16H21NO3
- 分子量275.34
- Beilstein号
- EC号 262-771-1
- MDL号 MFCD00270906
- PubChem编号 24278196
属性
| 熔点 | 130-134℃ |
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in water (0.2 mg/mL ), DMSO (7.3 mg/ml ), ethanol (7 mg/ml warm), DMF (~10 mg/ml ), DMF:PBS (pH 7.2, 1:9) (~0.5 mg/ml ), and acetone (25 mg/ml). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 |
Rolipram has been used: 1.to investigate its effects on testicular torsion-detorsion injury. 2.to block the effects of phosphodiesterase-4 (PDE4). 3.as a component in chemically induced long-term potentiation (cLTP) induction media. |
| 产品介绍 | Rolipram enhances tissue protection, anatomical repair and functional recovery. It is used to treat asthma, arthritis, Huntington′s disease and multiple sclerosis. Rolipram inhibits injury-induced reductions in cyclic AMP, which is associated with acute central nervous system injury. It functions as an antidepressant, stimulates neurite outgrowth and axonal regeneration in the presence of myelin inhibitors. |
| 备注 | Rolipram is a PDE4-inhibitor and an anti-inflammatory agent. |
| 生化机理 | Rolipram is a selective, cell-permeable inhibitor of cAMP-specific PDE (phosphodiesterase) (PDE4, IC50=1 μM). This compound has been shown to inhibit PDE4 activity in human cavernosal tissue, which interrupts the signal transduction pathway of erectile response. Rolipram promotes apoptosis in HL60 cells through a cAMP-independent mechanism and has been shown to enhance neuronal survival. Rolipram is an inhibitor of PDE4A1 and PDE4B. |
| 别名 | 咯利普兰;4-[3-(环戊氧基)-4-甲氧基苯基]-2-吡咯烷酮;ZK 62711;4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |
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