| 应用 |
A cell cycle arresting agent that inhibits DHFR. |
| 产品介绍 |
Methotrexate是一种抗代谢药物和抗叶酸制剂，具有抗肿瘤和免疫抑制剂活性。 |
| 备注 |
Abitrexate (Methotrexate) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. |
| 生化机理 |
Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate. |
| 别名 |
甲氨蝶呤; N-[4-[[(2,4-二氨基-6-蝶啶)甲基]甲氨基]苯甲酰]-L-谷氨酸;对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸;胺甲喋呤;CL14377; WR19039; 4-氨基-N10-甲基巯基-L-谷氨酸, MTX, 氟安定, 氨甲叶酸, 氨甲喋呤;(+)-Amethopterin;Abitrexate; Rheumatrex; Amethopterin; Trexall; CL14377; WR19039;(+)-4-Amino-10-methylfolic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid |
