MK-8245-分析测试百科网

MK-8245

面议

分子式 C17H16BrFN6O4 分子量467.26 属性溶解性 DMSO 93 mg/mL (199.03 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 m

400-6699-117 转1000

耗材描述

溶解性	DMSO 93 mg/mL (199.03 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM)
存贮条件	储存温度-20°C

产品介绍	MK-8245是一种靶向作用于肝脏的stearoyl-CoA desaturase (SCD)（硬脂酰辅酶A去饱和酶）抑制剂，作用于人类SCD1时，IC50为1 nM，作用于大鼠和小鼠SCD1时，IC50为3 nM，具有抗糖尿病和抗高脂血症作用。Phase 2。
备注	MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.
别名	5-[3-[4-(2-溴-5-氟苯氧基)-1-哌啶基]-5-异恶唑基]-2H-四氮唑-2-乙酸;MK 8245;MK8245;5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid