耗材描述

• 分子式 C₅₄H₈₈O₁₈
• 分子量1025.27
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

溶解性	Soluble in ethanol (5 mg/ml at 25 °C), methanol, DMF, DMSO (49 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).
存贮条件	储存温度-20°C

描述

应用	A macrolide antibiotic with immunosuppresive activity.
产品介绍	Elaiophylin大环内脂类抗菌素，作用于恶性疟原虫K1a 和布氏布锥虫GUTat 3.1 品系，具有抗原生动物活性，IC50分别为370 ng/mL和460 ng/mL。
备注	Elaiophylin shows antiprotozoal activity against Plasmodium falciparum K1a and Trypanosoma brucei brucei GUTat 3.1 strains with IC50 of 0.36 μM and 0.45 μM, respectively.
生化机理	Elaiophylin is a highly characteristic macrolide antibiotic that was first isolated from a culture of Streptomyces melanosporus. Elaiophylin demonstrates antifungal activity when combined with metabolite rapamycin. Elaiophylin shows shown cytotoxicity against mammalian tumor cells, protozoa, nematodes and antibacterial activity aganst gram-positive bacteria. The compound has also displayed immunosuppressive activity through inhibition of B-cell stimulation and inhibiting proliferation of lymphocytes stimulated by mitogens. Elaiophylin has been found to have antihelminthic to inhibit nitric oxide synthesis. Elaiophylin is an inhibitor of 5 α-Reductase and NOS.
别名	洋橄榄叶素;Azalomycin-B; Gopalamicin; Salbomycin;

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