耗材描述

• 分子式 C₇₂H₁₀₁N₁₇O₂₆
• 分子量1620.67
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

敏感性	对热敏感
溶解性	Soluble in water (100 mg/ml at 25 °C), ethanol (50 mM), methanol (5 mg/ml), DMSO (100 mM), and DMF.
存贮条件	储存温度-20°C

描述

应用	Calcium-dependent lipopeptide antibiotic.
产品介绍	Daptomycin 是一种新型脂肽类抗生素。
备注	Daptomycin is a novel lipopeptide antibiotic.
生化机理	Daptomycin is a lipopeptide antibiotic produced by Streptomyces roseosporus with reported in vitro bactericidal activity against gram-positive organisms. As a calcium-dependent antibiotic, Daptomycin has been reported to act on the cytoplasmic membrane and undergo a conformational change upon interaction with lipid membranes in a model system. After the conformational change occurs, the compound is inserted into the membrane and causes significant perturbations. Membrane depolarization and leakage occurs, causing death in susceptible organisms.
别名	达托霉素;达妥霉素;Dapcin;Cubicin;LY146032; LY 146032; LY-146032

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