| 应用 |
It is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies. |
| 产品介绍 |
Tolnaftate 是一种合成的硫代氨基甲酸酯，用作抗真菌剂。 |
| 备注 |
Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent. |
| 生化机理 |
It prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin. |
| 别名 |
托萘酯; 甲基(3-甲苯基)硫代氨基甲酸 O-2-萘酯;Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthyl Ester;O-2-Naphthyl Methyl(3-methylphenyl)carbamothioate;Aftate; Tinactin |
