耗材描述

• 分子式 C₂₀H₁₇FO₃S
• 分子量356.41
• EC号 253-819-2
• MDL号 MFCD00599589
• PubChem编号 24277737

属性

溶解性	Soluble in water (0.05 mg/ml at 25 °C), methanol (50 mg/ml), ethanol (9 mg/ml at 25 °C), DMSO (71 mg/ml at 25 °C), and DMF (~ 30 mg/ml).

描述

应用	Treatment of human colorectal cancer cell lines induces MRP1 and MRP3 but not other members of the MRP family. Reported to significantly increase the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-
产品介绍	Sulindac 是一种非甾体抗炎剂。
备注	Sulindac (Clinoril) is a non-steroidal anti-inflammatory agent of the arylalkanoic acid class.
生化机理	Sulindac inhibits the NF-κB pathway. Sulindac is a non-steroidal anti-inflammatory drug. Sulindac reduces the level and activity of several cyclin-dependent kinases (CDKs) and induces apoptosis. Sulindac metabolizes to sulindac sulfide, a Cox (cyclooxygenase) inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent. Sulindac is an inhibitor of Cox-1 and Cox-2.
别名	舒林酸; (Z)-5-氟-2-甲基-1-[4-(甲亚硫酰苯基)亚甲基]-1H-茚-3-醋酸;Aflodac; Sulinol; Sulreuma;MK-231;(Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; cis-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]-indene-3-acetic acid

标识符号	GHS06, GHS08
信号词	Danger
危害声明	H301-H317-H334-H361
警示性声明	P261-P280-P301 + P310-P342 + P311
个人防护设备	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECS	NK8226000
WGK德国	3

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