TIC10 Analogue-分析测试百科网

TIC10 Analogue

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：1

分子式 C24H26N4O 分子量386.49 属性溶解性 DMSO mg/mL Water mg/mL Ethanol mg/mL 存贮条件储存温度-20°C //decorateTable('product-attribute-sp

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
T129707-5mg	41276-02-2	询底价
T129707-100mg	41276-02-2	询底价
T129707-25mg	41276-02-2	询底价

耗材描述

分子式 C₂₄H₂₆N₄O
分子量386.49

属性

溶解性	DMSO mg/mL Water mg/mL Ethanol mg/mL
存贮条件	储存温度-20°C

描述

应用	A small molecule that induces TRAIL in a p53-independent manner
产品介绍	TIC10(ONC201 isomer)是口服活性的稳定化合物，能抑制Akt和ERK，能透过血脑屏障，可诱导TRAIL。
备注	TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics.
生化机理	TIC10 (TRAIL-inducing compound 10) is an orally active, stable and potent small molecule that has been shown to transcriptionally induce TRAIL and TRAIL-mediated cell death in a p53-independent manner. TIC10 also activates the gene Foxo3a by dually inactivating Akt and ERK. TIC10 crosses the blood-brain barrier and is expected to be useful as an antitumor therapeutic agent.
别名	ONC201, NSC 350625;2,6,7,8,9,10-六氢-10-[(2-甲基苯基)甲基]-7-(苯基甲基)咪唑并[1,2-a]吡啶并[4,3-d]嘧啶-5(3H)-酮;TRAIL-inducing Compound 10;TIC10 isomer; ONC201 isomer;2,6,7,8,9,10-Hexahydro-10-[(2-methylphenyl)methyl]-7-(phenylmethyl)imidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one

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