SB415286
面议
- 阿拉丁
- 生产商
- 国产
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分子式 C16H10ClN3O5 分子量359.72 EC号 MFCD04039789 MDL号 MFCD04039789 PubChem编号 24278412 属性 溶解性 DMSO 72 mg/mL Water <1 mg/mL
| 货号 | CAS号 | 操作 |
|---|---|---|
| S129720-10mg | 264218-23-7 | 询底价 |
| S129720-1mg | 264218-23-7 | 询底价 |
| S129720-50mg | 264218-23-7 | 询底价 |
耗材描述
- 分子式 C16H10ClN3O5
- 分子量359.72
- EC号 MFCD04039789
- MDL号 MFCD04039789
- PubChem编号 24278412
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | SB 415286 |
| 合法信息 | Sold for only research purposes |
| 备注 | SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β. |
| 生化机理 |
SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. 1 As a result of GSK3 inhibition, SB 415286 stimulates glycogen synthesis in the Chang human liver cell line with an EC50 value of 2.9 ?M. SB 415286 also protects primary neurons from death induced by the PI3-kinase pathway. |
| 别名 | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione;3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
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