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Olanzapine

CAS No. : 132539-06-1

MCE 国际站：Olanzapine

产品活性：Olanzapine (LY170053) 是一种选择性的、具有口服活性的单胺能拮抗剂，高亲和力结合 5-羟色胺 H1，5HT2A/2C，5HT3，5HT6 (K_i 分别为 7、4、11、57 和 5 nM)，多巴胺 D1-4 (K_i=11-31 nM)，毒蕈碱 M1-5 (K_i=1.9-25 nM) 和肾上腺素 α1 受体 (K_i=19 nM)。Olanzapine 是一种非典型的抗精神病剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Autophagy  |  Apoptosis

作用靶点：5-HT Receptor  |  Dopamine Receptor  |  mAChR  |  Adrenergic Receptor  |  Autophagy  |  Mitophagy  |  Apoptosis

In Vitro: Olanzapine binds weakly to GABAA, Benzodiazepine (BZD), and β-adrenergic receptors (K_i>10 μM) .
?Olanzapine induces autophagy in human SH-SY5Y neuronal cell line.
?Olanzapine (1-100 μM? for 144 h under serum starvation) results in a marked anti-proliferative effect in glioblastoma cell lines as well as glioma stem-like cells.
?Olanzapine also enhances Temozolomide (HY-17364)’s anti-tumor activity in glioblastoma cell lines.
?Olanzapine induces apoptosis and necrosis in glioblastoma cell lines.

In Vivo: Olanzapine (0.75, 1.5 and 3 mg/kg) evaluates body weight and periuterine fat mass, as well as insulin, non-esterified fatty acids, triglycerides, and glucose levels in mice

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