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CAS No. : 1642152-40-6
MCE 国际站:Trastuzumab duocarmazine
产品活性:Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) 是一种 HER2 靶向ADC, 可以在肿瘤细胞中被组织蛋白酶 B 识别并裂解,选择性靶向肿瘤细胞。Trastuzumab duocarmazine 具有抗肿瘤活性,可以用于子宫和卵巢癌肉瘤等相关癌症研究。
研究领域:Antibody-drug Conjugate/ADC Related
作用靶点:Antibody-Drug Conjugates (ADCs)
In Vitro: Trastuzumab duocarmazine (SYD985) (0.0001-100 μg/mL, 24 h) is lethal to both HER2- and HER2+ cells, and is 7-fold more lethal to HER2/NEU3+ cell lines with the IC50 value of 0.013 μg/mL compared to T-DM1 with the IC50 value of 0.096 μg/mL. More importantly, in HER2/NEU1+ cells, it is 54 times more potent in killing cells compared to T-DM1.
In Vivo: Trastuzumab duocarmazine (SYD985) (3 mg/kg or 10 mg/kg, i.v., once) significantly inhibits tumor growth and prolongs the survival cycle in CB-17 / SCID mice with HER2/neu 3+ cells, with effective in vivo anti-tumor activity.
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