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BCMA/TNFRSF17 Protein, Human

MCE 国际站：BCMA/TNFRSF17 Protein, Human

B Cell Maturation Antigen (BCMA) 也称为 TNFRSF17 或 CD269，是肿瘤坏死因子受体 (TNFR) 超家族的跨膜糖蛋白成员。BCMA 用作多发性骨髓瘤 (MM) 的生物标志物。BCMA 主要在 B 细胞增殖、存活以及分化为浆细胞方面发挥重要作用。BCMA/TNFRSF17 Protein, Human 是一种由大肠杆菌表达的重组蛋白，由 50 (A5-A54) 个氨基酸组成。

Synonyms: rHuBCMA; TNFRSF17; CD269; B-cell maturation protein; BCM

Species: Human

Source: E. coli

Biological Activity: The ED₅₀ is <40 ng/mL as measured by murine B cells, corresponding to a specific activity of >2.5 × 10⁴ units/mg.

研究背景：BCMA is expressed preferentially by mature B lymphocytes, with minimal expression in hematopoietic stem cells or nonhematopoietic tissue. BCMA is almost exclusively expressed on plasmablasts and PCs.
The amino acid sequence of human BCMA protein has low homology for mouse BCMA protein.
BCMA is a 184 amino acid and 20.2-kDa type III transmembrane glycoprotein, with the extracellular N terminus containing a conserved motif of 6 cysteines. BCMA has two agonist ligands: a proliferation-inducing ligand (APRIL) and B cell activating factor (BAFF). Upon binding of the ligands to BCMA, activates B cells (NF-κβ), rat sarcoma/mitogen-activated protein kinase (RAS/MAPK), and phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-PKB/Akt) signaling pathway. These pathways result in proliferation stimulation by modulating cell cycle checkpoints, increasing survival by upregulating anti-apoptotic proteins, and production of cell adhesion molecules, angiogenesis factors, and immunosuppressive molecules.
BCMA can be used as a promising antigen to target using a variety of immuno-therapy treatments including CART cells, for MM patients. BCMA markedly reduces plasma IgA, IgG, and IgM levels and splenic Ig heavy chain mRNA levels in mouse. In BCMA−/− mice, the long-term survival of PCs is impaired, but lack of BCMA has no effect in short-lived PCs, B cell development, or early humoral immune response, and the splenic architecture and germinal centers appear intact in these BCMA-deficient mice. BCMA overexpression significantly promotes in vivo growth of xenografted MM cells in murine models.

蛋白编号：Q02223 (A5-A54)

基因 ID：608

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子受体  |  B 细胞成熟抗原  |  CD 抗原  |  B 细胞 CD 蛋白  |  BCMA/CD269  |  CAR-T 相关蛋白  |  B 细胞成熟抗原

Categories：Cytokines and Growth Factors  |  TNF Superfamily  |  TNF Receptor Superfamily  |  B Cell Maturation Antigen (BCMA)  |  CD Antigens  |  B Cell CD Proteins  |  BCMA/CD269  |  CAR-T related Proteins  |  B Cell Maturation Antigen (BCMA)

货号: HY-P7132

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