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CAS No. : 117467-28-4
MCE 国际站:Cefditoren (Pivoxil)
产品活性:Cefditoren Pivoxil (ME 1207) 是一种广谱的第三代口服头孢菌素抗菌剂,对多种常见的 β 内酰胺酶具有增强的稳定性。Cefditoren Pivoxil 对革兰氏阴性菌和革兰氏阳性菌有活性。Cefditoren Pivoxil 可用于慢性支气管炎急性发作、社区获得性肺炎 (CAP)、链球菌性咽炎/扁桃体炎或单纯性皮肤和皮肤结构感染等感染疾病的研究。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Cefditoren (Pivoxil) shows good activity against pneumoniae, S. pyogenes, Staphylococcus aureus, H. influenzae and H. parainfluenzae, M. catarrhalis.
Organism | MIC50 (mg/L) | MIC90 (mg/L) | susceptible (%) |
Gram-positive organisms |
Streptococcus pneumoniae (untyped)a | 0.015-0.25 | 0.12-1 | |
PS | ≤0.008-0.03 | 0.015-0.25 | 99-100 |
PI | 0.06-0.5 | 0.25-0.5 | 94-100 |
PR | 0.25-1 | 0.5-2 | 7-100 |
S. pyogenes | ≤0.008-0.03 | 0.015-0.03 | 100 |
Staphylococcus aureus (MS) | 0.12-0.5 | 0.5-1 | 50-100 |
Gram-negative organisms |
Haemophilus | ≤0.008-≤0.03 | 0.015-0.13 | |
influenzae (untyped)b |
β-Lactamase + | ≤0.008-0.03 | 0.015-0.06 | 100 |
β-Lactamase - | ≤0.008-0.03 | 0.015-0.06 | 100 |
H. parainfluenzaeb | ≤0.03 | 0.06 | |
Moraxella | 0.03-0.5 | 0.25-1 | 96 |
catarrhalis (untyped)b |
β-Lactamase + | ≤0.03-0.25 | 0.12-0.5 | 100 |
β-Lactamase - | ≤0.008-0.03 | 0.015-0.06 | 100 |
a Including PS, PI and PR strains.
b Including both β-lactamase-positive and -negative strains.
MIC50/90=mean minimum inhibitory concentrations required to inhibit the growth of 50% or 90% of bacterial strains;
MS=susceptible to meticillin;
PI=intermediate susceptibility to penicillin;
PR=resistant to penicillin;
PS=susceptible to penicillin.
In Vivo: Pharmacokinetics in mice:
Cefditoren (mg/kg) | C0 (µg/ml) | t1/2 (h) | AUClast (µg× h/ml) | Tlast (h) |
6.25 | 53.0 | 0.9 | 30.4 | 6 |
12.5 | 168.4 | 1.1 | 64.1 | 8 |
25 | 232.5 | 0.9 | 101.3 | 8 |
50 | 290.6 | 1.1 | 124.4 | 8 |
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货号: HY-17452A
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