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IGFBP-2 Protein, Human (HEK293, His)

MCE 国际站：IGFBP-2 Protein, Human (HEK293, His)

IGFBP2 Protein, Human (HEK293, His) 是高亲和力结合蛋白家族成员 (IGFBP1-6)，在中枢神经系统胰岛素样生长因子 (IGF) 调控中发挥调控作用。

Synonyms: rHuIGF-BP-2, His; IBP-2; IGFBP-2; BP2

Species: Human

Source: HEK293

Biological Activity: 1. The ED₅₀ is <2 µg/mL as measured by FDC-P1 cells.
2. Measured by its ability to inhibit the biological activity of IGF-II on MCF-7 human breast cancer cells. The ED₅₀ for this effect is 0.1501 μg/ml in the presence of 14 ng/mL rhIGF-II, corresponding to a specific activity is 6.662×10³ units/mg.

研究背景：Insulin-like Growth Factor Binding Protein 2 (IGFBP2) is a member of the family of high-affinity binding proteins (IGFBP1-6) and appears to play a governing role in Insulin-like Growth Factor (IGF) regulation in the central nervous system. Insulin-like Growth Factor-Binding Proteins (IGFBPs) modulate the actions of secreted insulin-like growth facts (IGFs) by binding to them and increase the IGF halflife in the extracellular milieu and circulation by sequestering them in this bound form. IGFBPs either enhance or inhibit IGF actions on target cells; the individual IGFBPs either inhibit or potentiate IGF effects on osteoblasts in bone. Human Insulin-like Growth Factor-Binding Protein 5 (rhIGFBP-5) is a unique and most abundant IGFBP stored in bone, having a high specific binding affinity for hydroxyapatite and extracellular matrix proteins, therefore fixing it and its bound IGFs within bone. rhIGFBP-5 consistently stimulates osteoblast cell proliferation in vitro, thus increasing the number of osteoblasts.

蛋白编号：P18065 (F40-Q325)

基因 ID：3485

产品分类：细胞因子和生长因子  |  IGF 家族  |  胰岛素样生长因子结合蛋白 2

Categories：Cytokines and Growth Factors  |  IGF family  |  IGFBP-2

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