Warangalone 产品活性：Warangalone 是抗疟疾化合物，能够抑制 3D7 (氯喹敏感) 和 K1 (氯喹耐药) 寄生虫的生长， IC50 值分别为 4.8 μg/mL 和 3.7 μg/mL。 Warangalone 还可以抑制环 AMP 依赖性蛋白激酶催化亚基 (cAK)，其 IC50 值为 3.5 μM。 产品来源： https://www.medchemexpress.cn/Warangalone.html 研究领域：Anti-infection | TGF-beta/Smad | Stem Cell/Wnt 作用靶点：Parasite | PKA 来源：植物 | 豆科 | 刺桐 结构分类：黄酮类 | 异黄酮 | 酚类 | 多酚类 In Vitro: Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC50 of 3.5 μM. When HL-60 cells are exposed to Warangalone (30 μM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells. 相关产品：Chloroquine | Puromycin dihydrochloride | Staurosporine | Hygromycin B | Doxycycline hyclate | Bucladesine sodium | Acetaminophen | Anisomycin | H-89 dihydrochloride | Metronidazole | 8-Bromo-cAMP sodium salt | Kaempferol | Amphotericin B | Hydroxychloroquine | Monensin sodium | Dihydroartemisinin | Niclosamide | Berberine chloride | Artesunate | Acridine Orange hydrochloride | Ivermectin | Fasudil Hydrochloride | Eflornithine hydrochloride hydrate | Azithromycin | D-Mannitol | TPE-MI 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。